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Vaccines Against Drug Abuse
Author(s) -
Shen X Y,
Orson F M,
Kosten T R
Publication year - 2012
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.2011.281
Subject(s) - addiction , clinical pharmacology , medicine , drugs of abuse , drug , heroin , substance abuse , pharmacology , nicotine , clinical trial , psychiatry
The currently available medications for the treatment of drug abuse have had only limited success. Anti‐addiction vaccines, aimed at eliciting antibodies that block the pharmacological effects of drugs, have great potential for treating drug abuse. We review the status of two vaccines that are undergoing clinical trials (for cocaine and nicotine addiction) and two that are still in preclinical development (for methamphetamine and heroin addiction). We also outline the challenges and ethical concerns associated with the development of anti‐addiction vaccines and their use as future therapeutics. Clinical Pharmacology & Therapeutics (2012); 91 1, 60–70. doi: 10.1038/clpt.2011.281