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Stem Cell Senescence and Regenerative Paradigms
Author(s) -
Beltrami A P,
Cesselli D,
Beltrami C A
Publication year - 2012
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.2011.262
Subject(s) - senescence , regenerative medicine , cellular senescence , stem cell , microbiology and biotechnology , biology , computational biology , genetics , phenotype , gene
The term “cellular senescence” denotes a cellular response to several stressors that results in irreversible growth arrest, alterations of the gene expression profile, epigenetic modifications, and an altered secretome, all of which eventually impair the reparative properties of primitive cells, adding a layer of complexity to the field of regenerative medicine. The purpose of this review is to illustrate how cellular senescence could affect tissue repair and to propose interventions that aim at interfering with it. Clinical Pharmacology & Therapeutics (2012); 91 1, 21–29. doi: 10.1038/clpt.2011.262