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Pharmacogenomics: Application to the Management of Cardiovascular Disease
Author(s) -
Johnson J A,
Cavallari L H,
Beitelshees A L,
Lewis J P,
Shuldiner A R,
Roden D M
Publication year - 2011
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.2011.179
Subject(s) - pharmacogenomics , medicine , pharmacogenetics , clopidogrel , intensive care medicine , disease , aspirin , warfarin , bioinformatics , pharmacology , atrial fibrillation , biology , biochemistry , genotype , gene
The past decade has seen substantial advances in cardiovascular pharmacogenomics. Genetic determinants of response to clopidogrel and warfarin have been defined, resulting in changes to the product labels for these drugs that suggest the use of genetic information as a guide for therapy. Genetic tests are available, as are guidelines for incorporation of genetic information into patient‐care decisions. These guidelines and the literature supporting them are reviewed herein. Significant advances have also been made in the pharmacogenomics of statin‐induced myopathy and the response to β‐blockers in heart failure, although the clinical applications of these findings are less clear. Other areas hold promise, including the pharmacogenomics of antihypertensive drugs, aspirin, and drug‐induced long‐QT syndrome (diLQTS). The potential value of pharmacogenomics in the discovery and development of new drugs is also described. In summary, pharmacogenomics has current applications in the management of cardiovascular disease, with clinically relevant data continuing to mount. Clinical Pharmacology & Therapeutics (2011) 90 4, 519–531. doi: 10.1038/clpt.2011.179