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Linking Pharmacology to Clinical Reports: Cyclobenzaprine and Its Possible Association With Serotonin Syndrome
Author(s) -
Mestres J,
Seifert S A,
Oprea T I
Publication year - 2011
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.2011.177
Subject(s) - serotonin syndrome , context (archaeology) , serotonin , pharmacology , clinical pharmacology , 5 ht receptor , medicine , norepinephrine , receptor , biology , dopamine , serotonergic , paleontology
The link between cyclobenzaprine (Flexeril) administration and serotonin syndrome (SS) is subject to debate. Establishing such a connection is difficult because of the limited number of case reports available and the almost complete ignorance of its preclinical pharmacology. In this context, evidence is provided here that cyclobenzaprine blocks the serotonin and norepinephrine transporters and binds to another set of five serotonin receptors. SS should be considered when indicative signs occur in the context of cyclobenzaprine use. Clinical Pharmacology & Therapeutics (2011); 90 5, 662–665. doi: 10.1038/clpt.2011.177