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Calcium Cycling Proteins and Their Association With Heart Failure
Author(s) -
Hadri L,
Hajjar R J
Publication year - 2011
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.2011.161
Subject(s) - heart failure , excitation–contraction coupling , calcium metabolism , medicine , calcium , clinical pharmacology , homeostasis , intensive care medicine , cardiology , pharmacology
Heart failure (HF) has reached epidemic proportions in the United States and is one of the most important challenges to public health. Severe congestive HF is associated with substantial morbidity and mortality. HF afflicts approximately 5 million patients and contributes to 3 million hospitalizations and 300,000 deaths yearly. 1 Late‐stage HF has a poor prognosis, and therapeutic options are limited. Defective excitation–contraction (EC) coupling in HF may result from altered density or function of proteins relevant for Ca 2+ homeostasis. Clinical Pharmacology & Therapeutics (2011) 90 4, 620–624. doi: 10.1038/clpt.2011.161