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Cancer Pharmacogenomics
Author(s) -
Paugh S W,
Stocco G,
McCorkle J R,
Diouf B,
Crews K R,
Evans W E
Publication year - 2011
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.2011.126
Subject(s) - pharmacogenomics , cancer , medicine , clinical pharmacology , chemotherapy , pharmacology , oncology , bioinformatics , biology
Pharmacogenomics research is yielding molecular diagnostic tools that can be used to optimize the selection of medications and their doses for individual patients. Given the narrow therapeutic index of most anticancer agents and the serious consequences of undertreatment, cancer chemotherapy is a compelling therapeutic area for translation of pharmacogenomics to the clinic. This review addresses how inherited (germline) and acquired (somatic) sources of genome variability can alter the toxicity or efficacy of cancer chemotherapy. Clinical Pharmacology & Therapeutics (2011) 90 3, 461–466. doi: 10.1038/clpt.2011.126