Premium
Prediction of Torsade de Pointes From the QT Interval: Analysis of a Case Series of Amisulpride Overdoses
Author(s) -
Joy JP,
Coulter CV,
Duffull SB,
Isbister GK
Publication year - 2011
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.2011.107
Subject(s) - amisulpride , qt interval , prolongation , medicine , anesthesia , electrocardiography , cardiology , antipsychotic , schizophrenia (object oriented programming) , psychiatry
Electrocardiograms (ECGs) from a case series of 86 amisulpride overdose events in 66 patients were reviewed for abnormal QT intervals and torsade de pointes (TdP). Eight patients exhibited TdP. In this investigative case series, the magnitude of prolongation of the QT interval was a stronger predictor of TdP than the mere presence of a prolongation per se . Clinical Pharmacology & Therapeutics (2011) 90 2, 243–245. doi: 10.1038/clpt.2011.107