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Implications of Obesity for Drug Therapy: Limitations and Challenges
Author(s) -
Jain R,
Chung SM,
Jain L,
Khurana M,
Lau SWJ,
Lee JE,
Vaidyanathan J,
Zadezensky I,
Choe S,
Sahajwalla CG
Publication year - 2011
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.2011.104
Subject(s) - medicine , drug , desk , obesity , socioeconomic status , pharmacotherapy , pharmacokinetics , pharmacodynamics , pharmacology , intensive care medicine , environmental health , computer science , operating system , population
Obesity has become a worldwide challenge with significant health and socioeconomic implications. One of the major implications is its impact on drug therapy. In order to gain a better understanding of this impact, we surveyed the regulatory guidances, the newly approved molecular entity drug products, and drug product labels in the Physician's Desk Reference . This review summarizes the findings of the survey along with the existing knowledge on pharmacokinetic and pharmacodynamic changes associated with obesity. Clinical Pharmacology & Therapeutics (2011) 90 1, 77–89. doi: 10.1038/clpt.2011.104