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The Systems Biology Approach to Drug Development: Application to Toxicity Assessment of Cardiac Drugs
Author(s) -
Rodriguez B,
Burrage K,
Gavaghan D,
Grau V,
Kohl P,
Noble D
Publication year - 2010
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.2010.95
Subject(s) - cardiotoxicity , clinical pharmacology , drug development , pharmacology , drug , medicine , intensive care medicine , drug toxicity , risk analysis (engineering) , toxicity , toxicology , biology
Side effects account for most of the instances of failure of candidate drugs at late stages of development. These development failures contribute to the exorbitant cost of bringing new compounds to market: a single withdrawal can represent a loss of more than $1 billion. Many unwanted actions of drugs affect the heart, resulting in potentially proarrhythmic alteration of ion channel function. Because these can be fatal, potential electrophysiological cardiotoxicity is among the most stringent exclusion criteria in the licensing process. Clinical Pharmacology & Therapeutics (2010) 88 1, 130–134. doi: 10.1038/clpt.2010.95