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Dealing With the Evidence Dilemma in Genomics and Personalized Medicine
Author(s) -
Khoury M J
Publication year - 2010
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.2010.4
Subject(s) - personalized medicine , multidisciplinary approach , clinical pharmacology , dilemma , clinical practice , genomics , engineering ethics , stakeholder , alternative medicine , precision medicine , medicine , psychology , bioinformatics , pharmacology , sociology , biology , political science , family medicine , genetics , public relations , epistemology , engineering , social science , genome , pathology , philosophy , gene
In this commentary, I discuss how the promise of genomics and personalized medicine (GPM) is currently not matched by the evidence that supports its use in clinical practice. The mismatch between expectations and reality can be addressed by placing greater emphasis on multidisciplinary translation research and by stakeholder‐driven collaboration that uses such research to address various and occasionally competing factors affecting the integration of genomic discoveries into clinical practice. Clinical Pharmacology & Therapeutics (2010) 87 6, 635–638. doi: 10.1038/clpt.2010.4