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A Fresh Look at the Mechanism of Isoniazid‐Induced Hepatotoxicity
Author(s) -
Metushi IG,
Cai P,
Zhu X,
Nakagawa T,
Uetrecht JP
Publication year - 2011
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.2010.355
Subject(s) - idiosyncrasy , isoniazid , metabolite , clinical pharmacology , mechanism (biology) , pharmacology , medicine , tuberculosis , pathology , economics , epistemology , philosophy , finance
Isoniazid (INH)‐induced hepatotoxicity remains a significant clinical problem, and the current mechanistic hypothesis is incomplete; it is simply referred to as metabolic idiosyncrasy, 1 which is believed to involve cytotoxicity caused by bioactivation of acetylhydrazine, 2 a metabolite of INH. However, this hypothesis is based on animal studies, involving characteristics that are very different from those that pertain to hepatotoxicity in humans, such as delayed onset. This issue therefore deserves a fresh look. Clinical Pharmacology & Therapeutics (2011) 89 6, 911–914. doi: 10.1038/clpt.2010.355