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Hunting the Hedgehog Pathway
Author(s) -
Weiss G J,
Von Hoff D D
Publication year - 2010
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.2010.34
Subject(s) - hedgehog , hedgehog signaling pathway , clinical pharmacology , signalling pathways , biology , signal transduction , medicine , pharmacology , physiology , genetics
Since the observation nearly 50 years ago of cyclopic newborn lambs borne by ewes grazing on California corn lily, an explosion of discovery has ensued. The Hedgehog (HH) signaling pathway is perhaps one of the most exciting targets in cancer research today. Here we provide a summary of the HH signaling pathway and detail its clinical relevance for treatment of patients and future research directions. Clinical Pharmacology & Therapeutics (2010) 87 6, 743–747. doi: 10.1038/clpt.2010.34