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The Emerging Role of Electronic Medical Records in Pharmacogenomics
Author(s) -
Wilke RA,
Xu H,
Denny JC,
Roden DM,
Krauss RM,
McCarty CA,
Davis RL,
Skaar T,
Lamba J,
Savova G
Publication year - 2011
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.2010.260
Subject(s) - biobank , pharmacogenomics , context (archaeology) , observational study , medical record , data science , health care , medicine , computer science , bioinformatics , biology , pharmacology , political science , pathology , law , paleontology
Health‐care information technology and genotyping technology are both advancing rapidly, creating new opportunities for medical and scientific discovery. The convergence of these two technologies is now facilitating genetic association studies of unprecedented size within the context of routine clinical care. As a result, the medical community will soon be presented with a number of novel opportunities to bring functional genomics to the bedside in the area of pharmacotherapy. By linking biological material to comprehensive medical records, large multi‐institutional biobanks are now poised to advance the field of pharmacogenomics through three distinct mechanisms: (i) retrospective assessment of previously known findings in a clinical practice‐based setting, (ii) discovery of new associations in huge observational cohorts, and (iii) prospective application in a setting capable of providing real‐time decision support. This review explores each of these translational mechanisms within a historical framework. Clinical Pharmacology & Therapeutics (2011) 89 3, 379–386. doi: 10.1038/clpt.2010.260