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Nuclear Receptors, Inflammation, and Liver Disease: Insights for Cholestatic and Fatty Liver Diseases
Author(s) -
Arrese M,
Karpen S J
Publication year - 2010
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.2010.2
Subject(s) - nonalcoholic fatty liver disease , nuclear receptor , inflammation , cholestasis , disease , fatty liver , liver disease , bioinformatics , receptor , medicine , biology , transcription factor , immunology , gene , biochemistry
Members of the nuclear receptor (NR) superfamily of ligand‐activated transcription factors are players of substantial relevance in the regulation of hepatic gene expression. NRs direct normal physiology and metabolism, adaptations to liver disease, and responses to inflammation and toxins. They also contribute to the regenerative response. In this review, we summarize currently available experimental and clinical data, focusing on the role of NRs in cholestasis and nonalcoholic fatty liver disease (NAFLD). We also highlight the potential of NRs as targets for safe and effective therapeutic interventions.