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Update on New Antivirals Under Development for the Treatment of Double‐Stranded DNA Virus Infections
Author(s) -
Dropulic L K,
Cohen J I
Publication year - 2010
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.2010.178
Subject(s) - cidofovir , virology , vidarabine , herpes simplex virus , vaccinia , virus , medicine , hepatitis b virus , entecavir , biology , lamivudine , recombinant dna , biochemistry , fludarabine , gene , cyclophosphamide , surgery , chemotherapy
All the currently available antiviral agents used in the treatment of double‐stranded (ds) DNA viruses, with the exception of interferon‐α, inhibit the same target, the viral DNA polymerase. With increasing reports of the development of resistance of herpes simplex virus (HSV), cytomegalovirus (CMV), and hepatitis B virus (HBV) to some of these drugs, new antiviral agents are needed to treat these infections. Additionally, no drugs have been approved to treat several DNA virus infections, including those caused by adenovirus, smallpox, molluscum contagiosum, and BK virus. We report the status of 10 new antiviral drugs for the treatment of dsDNA viruses. CMX‐001 has broad activity against dsDNA viruses; 3 helicase–primase inhibitors, maribavir, and FV‐100 have activity against certain herpesviruses; ST‐246 inhibits poxviruses; GS‐9191 inhibits papillomaviruses; and clevudine and emtricitabine are active against HBV. Most of these drugs have completed at least phase I trials in humans, and many are in additional clinical trials. Clinical Pharmacology & Therapeutics (2010) 88 5, 610–619. doi: 10.1038/clpt.2010.178