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Antidotes for Alcohol and Glycol Toxicity: Translating Mechanisms Into Treatments
Author(s) -
McMartin K E
Publication year - 2010
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.2010.157
Subject(s) - antidote , pharmacology , ethylene glycol , methanol poisoning , clinical pharmacology , ethylene glycol poisoning , medicine , clinical toxicology , toxicity , toxicology , chemistry , methanol , biology , organic chemistry
Translational toxicology can be defined as the movement of potential antidotes for the treatment of poisonings from basic mechanistic research to the marketplace. Because poisonings are infrequent, the clinical development of antidotes is fraught with trials and tribulations. Academic scientists often conduct basic mechanistic work with antidotes but are infrequently involved in further drug development. This article presents the development of 4‐methylpyrazole (4MP) (fomepizole) as an antidote against toxic alcohol poisonings, particularly by methanol and ethylene glycol (EG). Clinical Pharmacology & Therapeutics (2010) 88 3, 400–404. doi: 10.1038/clpt.2010.157