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Approaches to Simultaneous Analysis of Frequency and Severity of Symptoms
Author(s) -
Plan E L,
Karlsson K E,
Karlsson M O
Publication year - 2010
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.2010.118
Subject(s) - clinical pharmacology , computer science , process (computing) , drug , action (physics) , drug action , intensive care medicine , medicine , medical physics , data science , computational biology , pharmacology , biology , physics , quantum mechanics , operating system
Mechanistic models that synthesize pharmacological and (patho)physiological process information provide a rich basis for the characterization of drug action. However, the underlying clinical data are often simplified in a manner that does not allow models to fully elucidate the structure of the drug effect. In this article, we describe data‐simplification strategies that are in routine use to describe disease symptoms and compare them with a model developed for handling the true complexities of the data. Clinical Pharmacology & Therapeutics (2010) 88 2, 255–259. doi: 10.1038/clpt.2010.118