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The Clinical Utility Index as a Practical Multiattribute Approach to Drug Development Decisions
Author(s) -
Poland B,
Hodge FL,
Khan A,
Clemen RT,
Wagner JA,
Dykstra K,
Krishna R
Publication year - 2009
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.2009.71
Subject(s) - drug development , transparency (behavior) , index (typography) , probabilistic logic , risk analysis (engineering) , computer science , development (topology) , management science , operations research , actuarial science , drug , medicine , business , artificial intelligence , pharmacology , economics , mathematics , mathematical analysis , computer security , world wide web
We identify some innovative approaches to predicting overall patient benefit from investigational drugs to support development decisions. We then illustrate calculation of a probabilistic clinical utility index (CUI), an implementation of multiattribute utility that focuses on clinical attributes. We recommend use of the CUI for the support of early drug development decisions because of its practicality, reasonable accuracy, and transparency to decision makers, at stages in which financial factors that may dominate later‐phase decisions are less critical. Clinical Pharmacology & Therapeutics (2009); 86 , 1, 105–108 doi: 10.1038/clpt.2009.71