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Obesity, Inflammation, and Cardiovascular Risk
Author(s) -
Mathieu P,
Lemieux I,
Després JP
Publication year - 2010
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.2009.311
Subject(s) - adipose tissue , context (archaeology) , inflammation , obesity , disease , medicine , bioinformatics , epidemiology , metabolic syndrome , dysfunctional family , endocrinology , biology , paleontology , clinical psychology
Obesity, a highly prevalent condition, is heterogeneous with regard to its impact on cardiovascular disease (CVD) risk. Epidemiological observations and metabolic investigations have consistently demonstrated that the accumulation of excess visceral fat is related to an increased risk of CVD as well as several metabolic and inflammatory perturbations. In the past decade, data from several studies have served to emphasize that atherosclerosis has an inflammatory component that may contribute to several key pathophysiological processes. Study data have also highlighted the finding that the expanded visceral fat is infiltrated by macrophages that conduct “cross‐talk” with adipose tissue through several significant mechanisms. In this review, we provide, in the context of CVD risk, an up‐to‐date account of the complex interactions that occur between a dysfunctional adipose tissue phenotype and inflammation. Clinical Pharmacology & Therapeutics (2010) 87 4, 407–416. doi: 10.1038/clpt.2009.311