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Addressing the Challenges of the Clinical Application of Pharmacogenetic Testing
Author(s) -
Ikediobi ON,
Shin J,
Nussbaum RL,
Phillips KA,
Walsh JM,
Ladabaum U,
Marshall D
Publication year - 2009
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.2009.30
Subject(s) - pharmacogenetics , medicine , medical physics , medline , intensive care medicine , computational biology , biology , genotype , genetics , biochemistry , gene
Pharmacogenomics aims to use molecular genetic markers to predict treatment outcome. Indeed, within the past decade there has been a rapid emergence of pharmacogenetic tests to aid clinicians in predicting efficacy or toxicity for some drugs. Despite this major advance in therapeutic drug management, there remain challenges to the appropriate use of pharmacogenetic tests. We discuss UGT1A1 pharmacogenetic testing to illustrate the knowledge gaps impeding widespread use of pharmacogenetic tests in the clinical setting. Clinical Pharmacology & Therapeutics (2009); 86 , 1, 28–31 doi: 10.1038/clpt.2009.30