Pediatric Dose Selection | Zendy

Abernethy D R | Zendy; Burckart G J | Zendy

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Pediatric Dose Selection

Author(s) -

Abernethy D R,

Burckart G J

Publication year - 2010

Publication title -

clinical pharmacology and therapeutics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.941

H-Index - 188

eISSN - 1532-6535

pISSN - 0009-9236

DOI - 10.1038/clpt.2009.292

Subject(s) - clinical pharmacology , selection (genetic algorithm) , pharmacokinetics , medical physics , medicine , drug , pharmacology , computer science , intensive care medicine , machine learning

Selection of a drug dose in pediatrics is generally based on no or incomplete pharmacokinetic data. Traditionally, allometric, or scaling, techniques have been used; however, they have inherent limitations and may not make optimal use of the drug‐specific clinical pharmacokinetic information that is available. Modeling is a tool that holds promise. The future challenge is to create a structured approach to determining pediatric doses for new therapeutic agents. Clinical Pharmacology & Therapeutics (2010) 87 3, 270–271. doi: 10.1038/clpt.2009.292

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