Premium
Intermittent Preventive Therapy for Malaria in Pregnancy: Is Sulfadoxine–Pyrimethamine the Right Drug?
Author(s) -
Parikh S,
Rosenthal P J
Publication year - 2010
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.2009.284
Subject(s) - sulfadoxine , pyrimethamine , sulfadoxine/pyrimethamine , malaria , medicine , pregnancy , drug , obstetrics , chloroquine , intensive care medicine , pediatrics , pharmacology , immunology , biology , genetics
Pregnant women are at particularly high risk for morbidity and mortality from malaria, and pregnancy can markedly affect drug pharmacokinetics, yet the pharmacokinetics of antimalarial drugs in pregnancy has been little studied. An important malaria‐control measure in Africa is intermittent preventive therapy (IPT) with sulfadoxine–pyrimethamine (SP) during pregnancy. We discuss IPT with SP in light of several concerns and highlight recent findings from a pharmacokinetic study of SP in this population. Clinical Pharmacology & Therapeutics (2010) 87 2, 160–162. doi: 10.1038/clpt.2009.284