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Inflammation: Planning for a Source of Pharmacokinetic/Pharmacodynamic Variability in Translational Studies
Author(s) -
Schmith V D,
Foss J F
Publication year - 2010
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.2009.258
Subject(s) - inflammation , pharmacodynamics , pharmacokinetics , pharmacology , clinical pharmacology , medicine , bioinformatics , biology
The impact of inflammation on variability in the pharmacokinetics (PK) and pharmacodynamics (PD) of drugs should be considered in the design, analysis, and interpretation of clinical pharmacology studies. Data suggest that the metabolism and transport of drugs, as well as the expression of receptors, may change in the presence of inflammation. The clinical implications of these changes are not straightforward; they may vary depending on whether the inflammation is active or controlled and may change with time and successful treatment of the inflammation.