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ABCG2 Polymorphism Is Associated With the Low‐Density Lipoprotein Cholesterol Response to Rosuvastatin
Author(s) -
Tomlinson B,
Hu M,
Lee V W Y,
Lui S S H,
Chu T T W,
Poon E W M,
Ko G T C,
Baum L,
Tam L S,
Li E K
Publication year - 2010
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.2009.232
Subject(s) - rosuvastatin , genotype , clinical pharmacology , pharmacology , pharmacokinetics , low density lipoprotein , medicine , pharmacogenetics , polymorphism (computer science) , drug , cholesterol , lipoprotein , endocrinology , chemistry , gene , biochemistry
The ATP‐binding cassette G2 ( ABCG2 ) c.421C>A (rs2231142) polymorphism influences the pharmacokinetics of rosuvastatin. We examined whether this polymorphism influences the low‐density lipoprotein cholesterol (LDL‐C)‐lowering efficacy of the drug. In 305 Chinese patients with hypercholesterolemia who were treated with rosuvastatin at a dosage of 10 mg daily, the c.421A variant was found to be significantly associated with greater reduction in LDL‐C level, in a gene‐dose‐dependent manner. As compared with subjects with the c.421CC genotype, those with the c.421AA genotype showed a 6.9% greater reduction in LDL‐C level, which would be equivalent to the effect obtained by doubling the dose of rosuvastatin. Clinical Pharmacology & Therapeutics (2010) 87 5, 558–562. doi: 10.1038/clpt.2009.232