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Genetic Influences on the Pharmacokinetics of Orally and Intravenously Administered Digoxin as Exhibited by Monozygotic Twins
Author(s) -
Birkenfeld A L,
Jordan J,
Hofmann U,
Busjahn A,
Franke G,
Krüger N,
Igel S,
Mürdter T,
Drescher S,
Shi S,
Engeli S,
Schwab M,
Eichelbaum M,
Luft F C,
Fromm M F
Publication year - 2009
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.2009.170
Subject(s) - digoxin , pharmacokinetics , pharmacogenetics , disposition , pharmacology , p glycoprotein , clinical pharmacology , medicine , drug , biology , genetics , drug resistance , gene , psychology , genotype , multiple drug resistance , heart failure , social psychology
The expression and function of the drug transporter P‐glycoprotein are highly variable. Environmental and genetic factors contribute to this variation. We studied the disposition of digoxin, a frequently used probe drug for P‐glycoprotein function in humans, in monozygotic (MZ) twins and found that digoxin pharmacokinetics after oral and intravenous administration are highly correlated within MZ twins, supporting the hypothesis of a robust contribution from genetic variance. Our study suggests that studies involving twins could be more widely applied to elucidate pharmacogenetics. Clinical Pharmacology & Therapeutics (2009) 86 6, 634–643. doi: 10.1038/clpt.2009.151