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The Influence of Chronic Renal Failure on Drug Metabolism and Transport
Author(s) -
Dreisbach AW
Publication year - 2009
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.2009.163
Subject(s) - clinical pharmacology , drug , bioavailability , pharmacology , pharmacokinetics , drug metabolism , parathyroid hormone , medicine , transporter , organic anion transporting polypeptide , metabolism , organic anion transporter 1 , chemistry , biochemistry , calcium , gene
Chronic renal failure (CRF) has been shown, in animal models and clinical studies, to significantly reduce nonrenal clearance and to alter the bioavailability of predominantly metabolized drugs. Phase II reactions and drug transporters such as P‐glycoprotein (P‐gp) and organic anion transporting polypeptide (OATP) are also affected. High levels of parathyroid hormone (PTH), cytokines, and uremic toxins are implicated in some of these effects, which have a clinically significant impact on drug disposition and increase the risk of adverse drug reaction. Clinical Pharmacology & Therapeutics (2009) 86 5, 553–556. doi: 10.1038/clpt.2009.163