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Challenges in Developing Evidence‐Based Drug Dosing Guidelines for Adults and Children Receiving Renal Replacement Therapy
Author(s) -
Mueller BA,
Smoyer WE
Publication year - 2009
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.2009.150
Subject(s) - dosing , renal replacement therapy , medicine , intensive care medicine , context (archaeology) , drug , clinical pharmacology , pharmacology , biology , paleontology
The challenges of appropriate drug dosing in patients with renal failure requiring renal replacement therapy (RRT) have been exacerbated by recent trends in both RRT technology and practices. Nearly all these changes have resulted in augmented drug clearance, making most existing RRT drug dosing recommendations obsolete. Many barriers exist to conducting research to update our knowledge of appropriate drug dosing in the context of contemporary RRT. Recommendations on how this research could be conducted, including the use of in vitro techniques, are offered here. Clinical Pharmacology & Therapeutics (2009) 86 5, 479–482. doi: 10.1038/clpt.2009.150