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A Truncated Erythropoietin Receptor EPOR‐T Is Associated With Hypertension Susceptibility
Author(s) -
Carruthers SG
Publication year - 2009
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.2009.119
Subject(s) - erythropoietin receptor , erythropoietin , receptor , pharmacology , medicine , endocrinology
Erythropoietin (EPO) and its analogs increase blood pressure (BP) in susceptible patients. The ratio of truncated to full EPO receptors (EPORs) in endothelial progenitor cells harvested from anemic patients receiving EPO while undergoing hemodialysis is related to the increased BP observed in these patients. Truncated EPORs exert a hypertensive effect by opposing full EPOR stimulation that augments cyclic guanosine monophosphate (GMP) in vascular endothelium. The contribution of this discovery to clinical practice is debatable. Clinical Pharmacology & Therapeutics (2009); 86 , 2, 134–136 doi: 10.1038/clpt.2009.119