Premium
A Holy Grail of Clinical Pharmacology: Prediction of Drug Pharmacokinetics and Pharmacodynamics in the Individual Patient
Author(s) -
Benet LZ
Publication year - 2009
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.2009.102
Subject(s) - clinical pharmacology , pharmacodynamics , pharmacokinetics , pharmacology , drug , cyp3a4 , medicine , pharmacogenetics , cytochrome p450 , holy grail , chemistry , metabolism , computer science , biochemistry , genotype , gene , world wide web
Predicting drug kinetics and dynamics in an individual patient is a worthy goal and has some chance of success for drugs subject to marked pharmacogenetic differences. Howeer, one should not expect any prediction success for drugs primarily metabolized by the major cytochrome P450 enzyme, CYP3A4, whether one uses an exogenous drug or an endogenous metabolic process, such as the oxidation of cortisol. Clinical Pharmacology & Therapeutics (2009); 86 , 2, 133–134 doi: 10.1038/clpt.2009.102