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Genetic Variation in Drug Transporters in Ethnic Populations
Author(s) -
Cropp CD,
Yee SW,
Giacomini KM
Publication year - 2008
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.2008.98
Subject(s) - drug metabolism , drug , pharmacogenetics , transporter , cytochrome p450 , pharmacology , biology , genetic variation , in vivo , distribution (mathematics) , clinical pharmacology , enzyme , genetics , gene , biochemistry , genotype , mathematical analysis , mathematics
Drug‐metabolizing enzymes and membrane transporters work in concert to play crucial roles in drug absorption, distribution, and elimination. It is well recognized that genetic variation in drug‐metabolizing enzymes contributes substantially to interindividual differences in drug response. With the notable exceptions of CYP1A1 and CYP2E1 , genes encoding cytochrome P450s, which are involved in the metabolism of >80% of all drugs used in clinical practice, are highly polymorphic. 1 Interethnic variation in the distribution and frequency of occurrence of variant alleles in drug‐metabolizing enzymes is known to alter the rate of drug metabolism in vivo , resulting in interethnic variation in drug disposition and response. Clinical Pharmacology & Therapeutics (2008); 84 , 3, 412–416 doi: 10.1038/clpt.2008.98