Premium
A Continuum for Using Placebo Interventions in Regional Anesthesia and Analgesia Studies
Author(s) -
Waisel DB,
Truog RD
Publication year - 2008
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.2008.87
Subject(s) - placebo , perioperative , anesthesia , psychological intervention , medicine , randomized controlled trial , informed consent , clinical trial , intensive care medicine , surgery , alternative medicine , psychiatry , pathology
The anesthesiologist Henry K. Beecher is commonly associated with his crusade for informed consent for research. 1 Less recognized is his contribution to the development of principles of randomized controlled trials through his emphasis on surgery as placebo to minimize bias. This article reviews Beecher's contribution and how it should be applied to modern studies of perioperative analgesia. Clinical Pharmacology & Therapeutics (2008); 84 , 1, 163–165 doi: 10.1038/clpt.2008.87