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Inhaled Anesthesia: The Original Closed‐Loop Drug Administration Paradigm
Author(s) -
Gupta DK,
Eger EI
Publication year - 2008
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.2008.85
Subject(s) - anesthetic , anesthesia , medicine , volatile anesthetic , clinical pharmacology , drug administration , pharmacology
We administer anesthetics to obtain therapeutic effects and minimize untoward side effects. Anesthetists can precisely control inhaled anesthetic concentrations by controlling end‐tidal volatile anesthetic concentrations. This degree of control eliminates the need for closed‐loop inhaled anesthetic systems. The low solubility of modern inhaled anesthetics adds to the stability and control of the anesthetic state; the effective inhaled concentration varies little during maintenance of anesthesia unless altered by the anesthetist. A less precise closed‐loop system applies a processed electroencephalogram (EEG) to assess depth of anesthesia and enable accurate delivery of volatile and intravenous anesthetics to maintain a stable state of anesthesia. 1 Clinical Pharmacology & Therapeutics (2008); 84 , 1, 15–18 doi: 10.1038/clpt.2008.85