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Pharmacokinetics and Pharmacodynamics of Intravenously Administered Anesthetic Drugs: Concepts and Lessons for Drug Development
Author(s) -
Kern SE,
Stanski DR
Publication year - 2008
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.2008.80
Subject(s) - clinical pharmacology , pharmacodynamics , anesthetic , medicine , pharmacology , pharmacokinetics , drug , anesthesiology , drug development , intensive care medicine , anesthesia
The drugs used in the clinical practice of anesthesiology, specifically the intravenously administered compounds that create the hypnotic aspect (unconsciousness) and the analgesic aspect (opiates) of an anesthetic, provide important insights into principles that can be applied to drug development in general. Additionally, research involving these drugs and their therapeutic applications has advanced some of the fundamental principles of pharmacokinetic (PK) and pharmacodynamic (PD) modeling. This article reviews several examples of anesthetic drugs used in clinical pharmacology and points out how they provide insights into methods of applying these modeling concepts to modern drug development in general. Clinical Pharmacology & Therapeutics (2008); 84 , 1, 153–157 doi: 10.1038/clpt.2008.80