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Plasma Concentrations of Oral Oxycodone Are Greatly Increased in the Elderly
Author(s) -
Liukas A,
Kuusniemi K,
Aantaa R,
Virolainen P,
Neuvonen M,
Neuvonen PJ,
Olkkola KT
Publication year - 2008
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.2008.64
Subject(s) - oxycodone , pharmacokinetics , ingestion , analgesic , medicine , plasma concentration , pharmacology , anesthesia , drug , oral administration , plasma levels , opioid , receptor
We compared the pharmacokinetics of 10 mg oral oxycodone in four groups of 10 patients each, aged 20–40, 60–70, 70–80, and 80–90 years. Patients aged 70–80 and 80–90 years had 50–80% higher mean exposure to oxycodone ( P < 0.05) and a twofold higher plasma oxycodone concentration ( P < 0.05) than the young adults 12 h after ingestion of the drug. Because oxycodone pharmacokinetics depend to a great extent on the age of the subject, it is important to titrate the analgesic dose individually, particularly in the elderly. Clinical Pharmacology & Therapeutics (2008); 84 , 4, 462–467 doi: 10.1038/clpt.2008.64