Premium
Lazarus's Gate: Challenges and Potential of Epigenetic Reprogramming of Somatic Cells
Author(s) -
Henderson JT
Publication year - 2008
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.2008.51
Subject(s) - reprogramming , somatic cell nuclear transfer , somatic cell , epigenetics , induced pluripotent stem cell , biology , microbiology and biotechnology , genetics , cell , embryonic stem cell , embryo , blastocyst , gene , embryogenesis
The past year has seen tremendous advances in epigenetic reprogramming of somatic cells. Direct genesis of pluripotent stem cells, in contrast to earlier somatic cell nuclear transfer (SCNT) techniques, removes significant ethical and regulatory concerns regarding the utilization of human oocytes and zygotes, and represents a significant step toward the development of nonxenogeneic production methods. While significant technical hurdles remain, this and related technologies are enabling new approaches toward clinical treatments, basic research and diagnostics, and drug evaluation. Clinical Pharmacology & Therapeutics (2008); 83 , 6, 889–893 doi: 10.1038/clpt.2008.51