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Personalized Therapeutics: HIV Treatment in Adolescents
Author(s) -
RakhmaniY,
Capparelli EV,
Anker JN
Publication year - 2008
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.2008.187
Subject(s) - clinical pharmacology , human immunodeficiency virus (hiv) , medicine , antiretroviral therapy , psychosocial , drug , pediatrics , pharmacology , immunology , viral load , psychiatry
Adolescents infected with human immunodeficiency virus (HIV) represent a heterogeneous group of pubertal children and young adults. Antiretroviral therapy (ART) in adolescents is complex and depends on multiple factors. The continued use of higher (weight‐ or surface‐based) pediatric doses can result in potentially toxic drug exposure, whereas early introduction of lower adult doses can lead to the development of drug resistance and virologic failure. The physiological and psychosocial changes during puberty create strong grounds for an individualized therapeutic approach in HIV‐infected adolescents. Clinical Pharmacology & Therapeutics (2008); 84 , 6, 734–740 doi: 10.1038/clpt.2008.187