Effects of Selective vs. Nonselective Cyclooxygenase Inhibition on Dynamic Renal Potassium Excretion: A Randomized Trial

Both selective and nonselective cyclooxygenase (COX) inhibitors can reduce potassium excretion and can produce or exacerbate hyperkalemia. 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 We investigated whether there is a difference between the effects of nonselective COX‐1/COX‐2 inhibitors and selective COX‐2 inhibitors on provoked dynamic renal potassium excretion. We apply a mixed‐effects model statistical approach that allows investigation of drug‐induced delays in reaching maximal potassium excretion, blunting/flattening of potassium handling curves, and shift/separation in potassium handling at peak potassium excretion. Clinical Pharmacology & Therapeutics (2008); 84 , 2, 208–211 doi: 10.1038/clpt.2008.16