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Effects of Selective vs. Nonselective Cyclooxygenase Inhibition on Dynamic Renal Potassium Excretion: A Randomized Trial
Author(s) -
Preston RA,
Afshartous D,
Alonso AB
Publication year - 2008
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.2008.16
Subject(s) - excretion , potassium , chemistry , pharmacology , cyclooxygenase , hyperkalemia , renal physiology , medicine , endocrinology , renal function , biochemistry , enzyme , organic chemistry
Both selective and nonselective cyclooxygenase (COX) inhibitors can reduce potassium excretion and can produce or exacerbate hyperkalemia. 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 We investigated whether there is a difference between the effects of nonselective COX‐1/COX‐2 inhibitors and selective COX‐2 inhibitors on provoked dynamic renal potassium excretion. We apply a mixed‐effects model statistical approach that allows investigation of drug‐induced delays in reaching maximal potassium excretion, blunting/flattening of potassium handling curves, and shift/separation in potassium handling at peak potassium excretion. Clinical Pharmacology & Therapeutics (2008); 84 , 2, 208–211 doi: 10.1038/clpt.2008.16