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Evaluating QTc in Patients With Advanced Parkinson's Disease: Overcoming Artifact
Author(s) -
Bloomfield DM
Publication year - 2009
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.2008.153
Subject(s) - qt interval , artifact (error) , clinical pharmacology , parkinson's disease , medicine , long qt syndrome , disease , pharmacology , psychology , neuroscience
Electrocardiograms (ECGs) in patients with Parkinson's disease are affected by artifacts related to muscle tremor. Malik et al . report methods used in QTc study in patients with Parkinson's disease that markedly reduce the noise and variance of QTc in a sample of ECGs that are undeniably difficult to interpret. This study adds significant experience and novel methods that have the potential to further enhance the evaluation of the effect of a drug on QTc. Clinical Pharmacology & Therapeutics (2009); 85 , 4, 365–366 doi: 10.1038/clpt.2008.153