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Early Drug Distribution: A Generally Neglected Aspect of Pharmacokinetics of Particular Relevance to Intravenously Administered Anesthetic Agents
Author(s) -
Henthorn TK,
Krejcie TC,
Avram MJ
Publication year - 2008
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.2008.107
Subject(s) - pharmacokinetics , medicine , anesthetic , drug , pharmacology , anesthesia , distribution (mathematics) , intensive care medicine , mathematical analysis , mathematics
There is considerable variability in response to intravenously administered anesthetic drugs (e.g., hypnotics, benzodiazepines, and narcotics) that have a rapid onset of effect (such as hypnosis, anxiolysis, and analgesia) and a low margin of safety (because of cardiovascular or respiratory depression, etc.). Although the onset of effect for these drugs occurs seconds to minutes after injection, traditional pharmacokinetic models are based on blood samples that are first obtained after drug effects have peaked. As a result, many studies have failed to provide a pharmacokinetic rationale for dosage adjustments of these drugs. Clinical Pharmacology & Therapeutics (2008); 84 , 1, 18–22 doi: 10.1038/clpt.2008.107