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Choline pharmacokinetics during intermittent intravenous choline infusion in human subjects
Author(s) -
Buchman Alan L,
Jenden Donald J,
Moukarzel Adib A,
Roch Margareth,
Rice Kathleen M,
Chang Ann S,
Ament Marvin E
Publication year - 1994
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1994.28
Subject(s) - choline , pharmacokinetics , compartment (ship) , volume of distribution , elimination rate constant , chemistry , urine , distribution volume , choline chloride , fluid compartments , anesthesia , distribution (mathematics) , pharmacology , medicine , extracellular fluid , biochemistry , extracellular , mathematical analysis , oceanography , mathematics , geology
A study of choline pharmacokinetics was undertaken in four patients receiving long‐term total parenteral nutrition. On consecutive days, 7, 14, 28, and 56 mmol choline chloride were intravenously infused over a 12‐hour period in each subject. The choline concentration was determined in plasma at baseline, ¼, 1, 3, 6, and 12 hours, and 3 and 12 hours after the infusion ended, and in daily 24‐hour urine collections. Analysis of variance showed the data fit a two‐compartment model in which elimination from the central compartment was saturable significantly better than a one‐compartment model in all four subjects ( p < 10 −8 in all cases), and significantly better than a nonsaturating model in three of the four subjects ( p = 1.0 × 10 −9 , 7.5 × 10 −6 , 9.4 × 10 −11 , respectively). The model allowed estimates of the rate constant for choline elimination at ambient levels, first‐order rate constants for transfer between central and peripheral compartments, the dissociation constant for the saturable elimination process, the apparent volume of distribution in the central compartment, the steady‐state volume of distribution, and the quantities of choline in the central compartment and in the readily exchangeable pool. Clinical Pharmacology and Therapeutics (1994) 55, 277–283; doi: 10.1038/clpt.1994.28