Premium
Amphetamine‐like effect of l ‐deprenyl (selegiline) in drug discrimination studies *
Author(s) -
Yasar Sevil,
Bergman Jack
Publication year - 1994
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1994.207
Subject(s) - selegiline , amphetamine , drug , pharmacology , medicine , dopamine , parkinson's disease , disease
l ‐Deprenyl has dose‐dependent amphetamine‐ and methamphetamine‐like discriminative stimulus properties in rats and monkeys. However, these actions occur only at doses that are well above the clinically relevant dose range for l ‐deprenyl and are likely to reflect its metabolic conversion to amphetamine products. In view of its weak potency for producing amphetamine‐like effects and their slow onset, it may not be surprising that l ‐deprenyl does not appear to have amphetamine‐like abuse potential and has been used therapeutically in the treatment of Parkinson syndrome for more than 20 years with no reported instances of abuse. Clinical Pharmacology and Therapeutics (1994) 56, 768–773; doi: 10.1038/clpt.1994.207