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Protein binding and ivermectin estimations in patients with onchocerciasis
Author(s) -
Okonkwo Paul O,
Ogbuokiri Justina E,
Ofoegbu Esther,
Klotz Ulrich
Publication year - 1993
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1993.46
Subject(s) - ivermectin , onchocerciasis , volume of distribution , saliva , pharmacokinetics , urine , bioavailability , onchocerca volvulus , albumin , area under the curve , medicine , blood plasma , pharmacology , chemistry , immunology , veterinary medicine
We measured ivermectin in plasma, urine, and saliva of nine patients with onchocerciasis. The aim was to establish pharmacokinetic parameters and to assess the most facile medium for use in monitoring compliance. Binding of ivermectin to plasma proteins in vitro was also investigated. The mean (± SEM) plasma values for the nine subjects were as follows: weight, 66.3 ± 2.8 kg; dose, 11.11 ± 0.4 mg; half‐life, 56.50 ± 7.01 hours; clearance, 142.5 ± 22.6 L/kg; volume of distribution, 9.91 ± 2.67 L/kg; area under the plasma concentration—time curve, 1545.3 ± 190.5 ng/ml · hr; time to reach maximum concentration, 4.7 ± 0.5 hours; and maximum concentration, 38.2 ± 5.8 ng/ml. Ivermectin was not detected in the urine of any of the nine subjects. Low levels were found in saliva. Blood specimens remain the only reliable biologic fluid for assessment of compliance after ivermectin oral administration. Ivermectin binds specifically to human serum albumin. Clinical Pharmacology and Therapeutics (1993) 53, 426–430; doi: 10.1038/clpt.1993.46