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The influences of dose and ethnic origins on the pharmacokinetics of nifedipine
Author(s) -
Ahsan Chowdhury H,
Renwick Andrew G,
Waller Derek G,
Challenor Viv F,
George Charles F,
Amanullah M
Publication year - 1993
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1993.155
Subject(s) - nifedipine , pharmacokinetics , medicine , metabolite , pharmacology , pharmacodynamics , area under the curve , clinical pharmacology , active metabolite , half life , oral administration , calcium
The pharmacokinetics of nifedipine capsules was investigated in healthy young Caucasian and South Asian subjects. Both the area under the plasma concentration–time curve (AUC) and terminal half‐life of nifedipine were significantly higher in South Asians compared with Caucasian subjects after single oral doses of 10 and 20 mg. The AUC and half‐life values of the nitropyridine metabolite were also higher in South Asians than in Caucasian subjects. The serum protein binding of nifedipine was similar in the two groups. The pharmacokinetics were essentially linear in both Caucasian subjects (0 to 30 mg; n = 27) and South Asians (0 to 20 mg; n = 16). There was no indication of a separate subgroup of Caucasian subjects with high AUC values equivalent to the poor metabolizers reported previously. Pharmacodynamic modeling for South Asians gave estimates comparable to those previously reported in Caucasian subjects. Patients of South Asian origin may require lower doses of nifedipine. Clinical Pharmacology and Therapeutics (1993) 54, 329–338; doi: 10.1038/clpt.1993.155