Premium
Age‐related digoxin‐alprazolam interaction
Author(s) -
Guven Hulya,
Tuncok Yesim,
Guneri Sema,
Cavdar Caner,
Fowler John
Publication year - 1993
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1993.107
Subject(s) - alprazolam , digoxin , medicine , serum concentration , clinical pharmacology , toxicity , drug interaction , pharmacology , anesthesia , pharmacokinetics , heart failure , psychiatry , anxiety
A case report of dramatic increases in serum digoxin levels after alprazolam administration prompted our investigation. Twelve inpatients receiving long‐term digoxin (0.25 mg daily) randomly received oral administration of either 1.0 or 0.5 mg alprazolam per day for 7 days. In each dosage group, three patients were older than and three were younger than 65 years of age. The area under the concentration‐time curve for serum digoxin increased significantly in patients receiving 1 mg alprazolam daily, and this increase was more pronounced in patients older than 65 years of age. Clinical digoxin toxicity developed in one elderly patient who was receiving 1 mg/day alprazolam. Clinical Pharmacology and Therapeutics (1993) 54, 42–44; doi: 10.1038/clpt.1993.107