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Gender and age as factors in the inhibition of renal clearance of amantadine by quinine and quinidine
Author(s) -
Gaudry Sherril E,
Sitar Daniel S,
Smyth Donald D,
McKenzie John K,
Aoki Fred Y
Publication year - 1993
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1993.104
Subject(s) - quinidine , amantadine , quinine , pharmacology , renal function , medicine , crossover study , malaria , alternative medicine , pathology , immunology , placebo
We studied the short‐term effect of oral doses of quinine and quinidine on the renal clearance of amantadine in healthy young (age range, 27 to 39 years) and older (age range, 60 to 72 years) adults of both genders in a three‐limbed randomized crossover study. Renal clearance of amantadine (13.2 ± 5.8 L/hr) was significantly inhibited by quinine (9.7 ± 4.8 L/hr) and quinidine (8.9 ± 4.0 L/hr) only in male subjects and was not associated with age. The chiral selectivity for the renal clearance of quinidine over quinine was confirmed and extended with the suggestion of both age‐ and gender‐associated changes on the renal clearance ratio for these two diastereomeric drugs. These data support the continued use of amantadine for studies on the renal elimination of organic cationic drugs. Clinical Pharmacology and Therapeutics (1993) 54, 23–27; doi: 10.1038/clpt.1993.104