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Effects of celiprolol on cardiovascular reactivity to laboratory stressors in patients with hypertension
Author(s) -
Cardillo Carmine,
Degen Claudia,
De Felice Francesco,
Folli Giuseppe
Publication year - 1992
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1992.62
Subject(s) - celiprolol , blood pressure , placebo , medicine , vasodilation , essential hypertension , cardiology , diastole , heart rate , anesthesia , pathology , alternative medicine
An ideal antihypertensive drug should reduce blood pressure not only at rest but also during stressful situations. To test whether this criterion is fulfilled by celiprolol, a new β 1 ‐selective adrenergic blocker drug with peripheral vasodilating activity, we examined the effects of its oral administration on cardiovascular reactivity to laboratory stressors in 18 patients with essential hypertension, according to a placebo‐controlled crossover design. In the 12 patients classified as “responders,” celiprolol significantly reduced resting systolic and diastolic blood pressure ( p < 0.05 for both). Compared with placebo, celiprolol induced a blood pressure reduction from 179.4 ± 16.9/119.5 ± 12.4 mm Hg to 160.7 ± 12.6/109.4 ± 3.1 mm Hg during mental arithmetic; from 200.9 ± 20.7/139.2 ± 11.9 mm Hg to 184.1 ± 16.4/127.6 ± 12.1 mm Hg during handgrip test; from 212.8 ± 18.5/126.2 ± 14.2 mm Hg to 185.9 ± 18.2/117.1 ± 15.2 mm Hg during cycle ergometry. Our data suggest that in the majority of treated patients celiprolol is effective in reducing blood pressure not only at rest but also during a variety of stressful events, thereby ameliorating the impact of recurring stress‐induced increases of blood pressure on the cardiovascular system. Clinical Pharmacology and Therapeutics (1992) 51 , 555–561; doi: 10.1038/clpt.1992.62