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Pharmacokinetics and pharmacodynamics of ranitidine after burn injury
Author(s) -
Martyn J A J,
Bishop A L,
Oliveri M F
Publication year - 1992
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1992.40
Subject(s) - ranitidine , pharmacokinetics , medicine , pharmacodynamics , volume of distribution , bolus (digestion) , anesthesia , dosing , pharmacology , histamine h2 receptor , intravenous bolus , antagonist , receptor
The pharmacokinetics and pharmacodynamics of ranitidine were studied in 10 hypermetabolic burned patients with normal creatinine clearance and compared with healthy volunteers. Ranitidine was administered as a single 50 mg intravenous bolus and multiple blood samples were obtained up to 10 hours after the dose for determination of plasma ranitidine concentrations. Gastric pH in burned patients was monitored by way of a nasogastric tube. Burned patients exhibited significanlty higher ( p < 0.01) ranitidine clearance (mean ± SD; 10.80 ± 2.38 versus 7.53 ± 1.71 ml/min/kg) and steady‐state distribution volume (1.63 ± 0.13 versus 1.16 ± 0.33 L/kg). Within an hour of administration of drug the gastric pH was ≥4.0 in all but one patient. This pH was maintained for at least 6 hours. In five patients the pH was ≥4.0 throughout the 10‐hour study. Thus, despite increased ranitidine clearance, the recommended dose of ranitidine maintained gastric pH >4.0 throughout the normal dosing interval in the majority of patients. Dosage adjustment reported for many other drugs after burn injury may not be necessary for ranitidine. Clinical Pharmacology and Therapeutics (1992) 51, 408–414; doi: 10.1038/clpt.1992.40