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Influence of lansoprazole treatment on diazepam plasma concentrations
Author(s) -
Lefebvre Romain A,
Flouvat Bernard,
KarolacTamisier Sara,
Moerman Emmanuel,
Ganse Eric Van
Publication year - 1992
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1992.172
Subject(s) - lansoprazole , diazepam , pharmacokinetics , volume of distribution , placebo , crossover study , pharmacology , plasma clearance , chemistry , plasma concentration , drug interaction , medicine , omeprazole , pathology , alternative medicine
The possible influence of long‐term treatment with lansoprazole on the single‐dose pharmacokinetics of diazepam was investigated in 12 healthy male volunteers. In this double‐blind randomized crossover study, 60 mg lansoprazole or placebo was administered once daily for 10 days. One hour after administration on day 7, 0.1 mg/kg diazepam was administered intravenously, and blood was collected up to 96 hours after the injection for plasma diazepam and desmethyldiazepam measurement. During the placebo session, the plasma elimination half‐life, clearance, and volume of distribution of diazepam were 26.0 ± 1.6 hours, 22.5 ± 1.1 ml/hr/kg, and 0.82 ± 0.04 L/kg, respectively. These parameters were not significantly different during the lansoprazole session. The mean plasma concentrations of desmethyldiazepam were similar in both sessions. These findings illustrate that long‐term treatment with a therapeutic dose of lansoprazole does not interfere with the metabolism of diazepam. Clinical Pharmacology and Therapeutics (1992) 52, 458–463; doi: 10.1038/clpt.1992.172