Premium
Fluvoxamine does not interact with alcohol or potentiate alcohol‐related impairment of cognitive function
Author(s) -
Harten Jaap,
Stevens Lloyd A,
Raghoebar Maikel,
Holland Robert L,
Wesnes Keith,
Cournot Antoine
Publication year - 1992
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1992.166
Subject(s) - fluvoxamine , pharmacokinetics , alcohol , pharmacodynamics , pharmacology , placebo , anesthesia , medicine , psychology , crossover study , adverse effect , cognition , psychiatry , chemistry , pathology , fluoxetine , biochemistry , receptor , alternative medicine , serotonin
Objective : To assess whether fluvoxamine alters the pharmacokinetics of alcohol or potentiates alcohol‐related impairment of cognitive function. Methods : The study design required partially “blinded” balanced crossover studies, each involving 12 healthy male volunteers who each received a 40 gm dose of intravenous or oral alcohol after single and multiple doses of 50 mg fluvoxamine. Main outcome measures for pharmacokinetics were venous blood alcohol and plasma fluvoxamine. Main outcome measures for pharmacodynamics were word recall, simple and choice reaction time, number vigilance, memory scanning, and word recognition. Results : The pharmacokinetics of intravenous alcohol were not affected by concomitant administration of fluvoxamine. Compared with placebo‐alcohol, alcohol slightly increased the rate of fluvoxamine absorption, but the area under the plasma concentration‐time curve from 0 to 12 hours at steady state was unchanged. As expected, alcohol significantly impaired cognitive function in volunteers. However, fluvoxamine did not potentiate the effects of alcohol and in some instances appeared to reverse the effects or reduce their duration. Fluvoxamine was well tolerated: only mild adverse effects were reported, and none of those required intervention. Conclusion : Fluvoxamine does not interact significantly with alcohol or potentiate alcohol‐related impairment of cognitive function. Clinical Pharmacology and Therapeutics (1992) 52, 427–435; doi: 10.1038/clpt.1992.166