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The efficacy of locally applied aspirin and acetaminophen in postoperative pain after third molar surgery
Author(s) -
Moore Undrell J,
Seymour Robin A,
Rawlins Michael D
Publication year - 1992
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1992.144
Subject(s) - acetaminophen , medicine , aspirin , placebo , analgesic , anesthesia , molar , visual analogue scale , oral surgery , adverse effect , surgery , dentistry , pharmacology , alternative medicine , pathology
This study evaluated the efficacy of and investigated the site of action of aspirin and acetaminophen placed directly into tooth sockets after bilateral third molar surgery under local anaesthesia. On completion of surgery, 12 patients received in random, blind order either a suspension of aspirin in a methyl cellulose gel (100 mg/ml) in their tooth sockets and an oral placebo or the methyl cellulose alone in their sockets and an oral dose of aspirin (50 mg). The remaining 12 patients were treated in the same fashion with use acetaminophen. Patients were asked to record their pain, at intervals, over an 8‐hour period on a 10 cm visual analog scale. Significantly less pain ( p < 0.05) was recorded throughout the 8‐hour investigation period after both locally placed drugs than after placebo. There was no adverse effect on healing. The peripheral activity of aspirin is confirmed, and our findings suggest that acetaminophen has a significant peripheral effect in mediating its analgesic properties in postoperative pain after third molar surgery. Clinical Pharmacology and Therapeutics (1992) 52 , 292–296; doi: 10.1038/clpt.1992.144